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||BRAND NAME : Glucophage
CHEMICAL CONTENTS: Metformin HCL or Glipizide
Glucophage is an oral antidiabetic medication used to treat type 2 (non-insulin-dependent) diabetes. Diabetes develops when the body proves unable to burn sugar and the unused sugar builds up in the bloodstream. Glucophage lowers the amount of sugar in your blood by decreasing sugar production and absorption and helping your body respond better to its own insulin, which promotes the burning of sugar. It does not, however, increase the body's production of insulin.
Glucophage is sometimes prescribed along with insulin or certain other oral antidiabetic drugs such as Micronase or Glucotrol . It is also used alone.
Standard Glucophage tablets are taken two or three times daily. An extended-release form (Glucophage XR) is available for once-daily dosing.
Adults : The usual starting dose is one Glucophage 500 mg tablet twice a day, taken with morning and evening meals. Your doctor may increase your daily dose by Glucophage 500 mg at weekly intervals, based on your response up to a total of 2,000 mg.
An alternative starting dose is one Glucophage 850 mg tablet a day, taken with the morning meal. Your doctor may increase this by Glucophage 850 mg at 14-day intervals, to a maximum of 2,550 mg a day.
The usual maintenance dose Glucophage ranges from 1,500 to 2,550 mg daily. If you take more than 2,000 mg a day, your doctor may recommend that the medication be divided into three doses, taken with each meal.
For children 10 to 16 years old, the usual starting dose is one Glucophage 500 mg tablet twice a day with meals. The dosage may be increased by Glucophage 500 mg at weekly intervals up to a maximum of 2,000 mg daily. Glucophage has not been tested in children younger than 10.
Glucophage Contraindications :
Avoid Glucophage if it has ever given you an allergic reaction.
If you have congestive heart failure, do not take Glucophage. This condition increases your risk of developing lactic acidosis.
Do not take Glucophage if you are suffering from acute or chronic metabolic acidosis, including diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, pain below the breastbone, and fruity breath).
You should not take Glucophage for 2 days before and after having an X-ray procedure with an injectable contrast agent (radioactive iodine). Also, if you are going to have surgery, except minor surgery, you should stop taking Glucophage. Once you have resumed normal food and fluid intake, your doctor will tell you when you can go back to therapy with Glucophage.
If you have kidney or liver disease or develop serious conditions such as a heart attack, severe infection, or a stroke, do not take Glucophage.
You should not take Glucophage if you are seriously dehydrated, having lost a large amount of fluid from severe vomiting, diarrhea, or high fever.
If you lose control of your blood sugar due to the stress of a fever, injury, infection, or surgery, your doctor may temporarily take you off of Glucophage and ask you to take insulin instead.
Glucophage Side Effects:
If side effects from Glucophage occur, they usually happen during the first few weeks of therapy. Most side effects are minor and will go away after you've taken Glucophage for a while.
More common side effects may include : Abdominal discomfort, diarrhea, gas, headache, indigestion, nausea, vomiting, weakness
An overdose of Glucophage can cause lactic acidosis. (See "What Side Effects May Occur?") If you suspect a Glucophage overdose, seek emergency treatment immediately.
Glucophage Missed dose:
Take Glucophage as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
Store Glucophage at room temperature.
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