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Insulin Aspart (rDNA Origin) Injection : Uses, Dosage, Contraindications, Side Effects, Overdose


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BRAND NAME :  Insulin Aspart (rDNA Origin) Injection

Brand Names:


Medication prescribed:

Insulin aspart is used to treat type 1 (insulin-dependent) diabetes (formerly called 'juvenile-onset'). It is also used to treat people with type 2 (noninsulin-dependent) diabetes (formerly called 'adult-onset') who need insulin to control their diabetes. Insulin aspart is a short-acting, man-made version of human insulin. It works by helping move sugar from the blood into other body tissues where it is used for energy. It also stops the liver from producing more sugar.

How should this medicine be used:

Insulin aspart comes as a solution (liquid) to inject subcutaneously (under the skin). It is usually injected immediately before meals (5–10 minutes before eating). Insulin aspart can also be infused under the skin using an external insulin pump. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use insulin aspart injection exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Because insulin aspart is a short-acting insulin, it may be used as an injection in combination with some other longer-acting insulins. If insulin aspart is mixed with NPH human insulin, insulin aspart should be drawn into the syringe first, and the solution should be injected immediately after mixing. When insulin aspart is used in an insulin pump, it should not be diluted or mixed with any other insulin or solution. Insulin aspart controls diabetes but does not cure it. Continue to use insulin aspart even if you feel well. Do not stop using insulin aspart without talking to your doctor. Do not switch to another brand or type of insulin or change the dose of any type of insulin you are using without talking to your doctor. Insulin aspart comes in vials, cartridges that contain medication and are to be placed in dosing pens, and dosing pens that contain cartridges of medication. Be sure you know what type of container your insulin aspart comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication. If your insulin aspart comes in vials, you will need to use syringes to inject your dose. Ask your doctor or pharmacist if you have questions about the type of syringe you should use. If your insulin aspart comes in cartridges, you will need to buy an insulin pen separately. Check the manufacturer's information for the patient to see what type of pen is right for the cartridge size you are using. Carefully read the instructions that come with your pen, and ask your doctor or pharmacist to show you how to use it. Ask your doctor or pharmacist if you have questions about the type of pen you should use. If your insulin aspart comes in pens, be sure to read and understand the manufacturer's instructions. Ask your doctor or pharmacist to show you how to use the pen. Follow the directions carefully. Never remove the cartridge from the pen or attempt to add any other type of insulin to the cartridge. Never reuse needles or syringes and never share needles, syringes, cartridges, or pens. If you are using an insulin pen, always remove the needle right after you inject your dose. Throw away needles and syringes in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture resistant container. Always look at your insulin aspart before you inject it. It should be as clear, colorless, and fluid as water. Do not use your insulin aspart if it is colored, cloudy, thickened, or contains solid particles, or if the expiration date on the bottle has passed. If your insulin aspart comes in vials, follow these steps to prepare your dose: Wash your hands. If you are using a new bottle, flip off the plastic cap, but do not remove the stopper. Wipe the top of the bottle with an alcohol swab. Pull back the plunger of the syringe until the top of the plunger is even with the dose your doctor told you to inject. Push the needle through the rubber stopper on the bottle. Push down on the plunger to inject the air into the bottle. Turn the bottle upside down without removing the syringe. Be sure the tip of the needle is under the liquid in the bottle. Slowly pull back on the plunger until the top of the plunger is even with the dose your doctor told you to inject. While the needle is still in the bottle, check whether there are air bubbles in the syringe. If there are bubbles, hold the syringe upright and tap on it to push the bubbles to the top. Push the plunger up to move the bubbles out of the syringe, and then pull the plunger back down to the correct dose. Remove the needle from the bottle and lay the syringe down so that the needle is not touching anything. To inject a prepared dose of insulin aspart using a syringe or pen, follow these steps: Use an alcohol pad to wipe the area where you plan to inject your medication. Pinch up a large area of skin, or spread the skin flat with your hands. Insert the needle into your skin. Your doctor will tell you exactly how to do this. If you are using a syringe, push the plunger all the way down. If you are using a pen, follow the manufacturer's instructions for dispensing a dose. Pull the needle out and press down on the spot for several seconds, but do not rub it. Use a different site for each injection, about 1 inch away from the previous injection but in the same general area (for example, the thigh). Use all available sites in the same general area before switching to a different area (for example, the upper arm). Do not use the same injection site more often than once every month. If you use insulin aspart in an insulin pump, change the tubing and needle and throw away any solution left in the reservoir at least every 48 hours. You should also change the injection site at least every 48 hours.

Other uses for this medicine:

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Special precautions:

Before using insulin aspart injection, tell your doctor and pharmacist if you are allergic to insulin (Humulin, Iletin, Novolin, Velosulin, others) or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); clonidine (Catapres, Catapres-TTS); danazol (Danocrine); disopyramide (Norpace, Norpace CR); diuretics ('water pills'); fenofibrate (Lofibra, TriCor); fluoxetine (Prozac, Sarafem); gemfibrozil (Lopid); guanethidine (Ismelin); hormone replacement therapy; isoniazid (INH, Laniazid, Nydrazid); lithium (Eskalith, Lithobid, Lithotabs); medications for asthma, colds, mental illness, and nausea; monoamine oxidase (MAO) inhibitors, including phenelzine (Nardil) and tranylcypromine (Parnate); niacin (nicotinic acid, Niaspan, Slo-Niacin); oral contraceptives (birth control pills); oral medications for diabetes; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); pentamidine (NebuPent, Pentam 300);propoxyphene; reserpine (Serpalan, Serpasil); salicylate pain relievers such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics; and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had nerve damage caused by your diabetes or kidney or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using insulin aspart, call your doctor.

Special dietary instructions:

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet. Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are using insulin aspart.

If I forget a dose:

Insulin aspart must be injected shortly before or after a meal. If you remember your dose before or shortly after your meal, inject the missed dose right away. If some time has passed since your meal, call your doctor to find out whether you should inject the missed dose. Do not inject a double dose to make up for a missed one.

What side effects:

You should know the symptoms of low and high blood sugar and what to do if you have them. Eat or drink a food or beverage with sugar in it, such as hard candy or fruit juice, and call your doctor immediately if you have any of the symptoms of hypoglycemia (low blood sugar) : shakiness dizziness or lightheadedness sweating confusion nervousness or irritability sudden changes in behavior or mood headache numbness or tingling around the mouth weakness pale skin sudden hunger clumsy or jerky movements seizures Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar) : extreme thirst frequent urination extreme hunger weakness blurred vision If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of the these symptoms: dry mouth upset stomach and vomiting shortness of breath breath that smells fruity decreased consciousness Insulin aspart injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: redness, swelling, or itching at the site of the injection changes in the feel of your skin, skin thickening (fat build-up), or a little depression in the skin (fat breakdown) Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: rash and/or itching over the whole body shortness of breath wheezing dizziness blurred vision fast heartbeat sweating Insulin aspart may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions:

Store unopened insulin aspart vials, cartridges, and pens in the refrigerator. Do not freeze. Unopened refrigerated insulin aspart can be stored until the date shown on the company's label. If no refrigerator is available (for example, when on vacation), store the vials or cartridges at room temperature and away from direct sunlight and extreme heat. Unrefrigerated vials, cartridges, and pens can be used within 28 days or they must be thrown away. Opened vials can be stored for 28 days at room temperature or in the refrigerator. Opened cartridges and pens may be stored at room temperature for up to 28 days; do not refrigerate them. Throw away any insulin aspart that has been exposed to extreme heat or cold. When traveling, protect your insulin aspart vials, cartridges, and pens from bumps or other rough handling (wrap them in clothes in the middle of a suitcase). Do not keep insulin in hot areas of a car such as the glove compartment or trunk. When traveling by airplane, do not put insulin in checked luggage since the luggage may be lost. Always keep insulin with you or in carry-on luggage. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of overdose:

In case of overdose, call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services at 911. Symptoms of overdose may include the symptoms of hypoglycemia listed above and the following: loss of consciousness confusion

Other information:

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to insulin aspart. To monitor the effectiveness of insulin aspart, measure the amount of sugar (glucose) in your blood or urine (when blood sugar is above a certain high level, you will have sugar in your urine). For measuring the amount of glucose in your blood, you can use a blood glucose meter. For the urine measurements, you will need special paper tapes, tablets, or plastic strips that change color depending on how much sugar is present. Your doctor also may ask you to test your urine for ketones (substances present when diabetes is not under control). Follow your doctor's directions for testing your urine and blood and for recording the results. If your blood sugar is high or if sugar or ketones are present in your urine, call your doctor. Your dose of insulin aspart may need to be changed when you are ill (especially with fever, vomiting, or diarrhea), have emotional changes or stress, gain or lose weight, or change the amount of food you eat or amount of exercise you do. If any of these things happen, call your doctor. See your dentist twice yearly; see your eye doctor regularly; get your blood pressure checked regularly. If you travel across time zones, ask your doctor how to time your injections. When you travel, take extra insulin and supplies with you. Keep yourself and your clothes clean. Wash cuts, scrapes, and other wounds quickly, and do not let them get infected. Wear medical alert identification (a bracelet or tag) that says you have diabetes. Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

More information:    Insulin Aspart (rDNA Origin) Injection

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