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Interferon beta-1a Intramuscular Injection : Uses, Dosage, Contraindications, Side Effects, Overdose


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BRAND NAME :  Interferon beta-1a Intramuscular Injection

Brand Names:


Medication prescribed:

Interferon beta-1a is used to prevent episodes of symptoms and slow the development of disability in patients with relapsing-remitting multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle coordination and problems with vision, speech, and bladder control). Interferon beta-1a has not been shown to help patients with chronic progressive MS. Interferon beta-1a is in a class of medications called immunomodulators. It is not known how interferon beta-1a works to treat MS.

How should this medicine be used:

Interferon beta-1a intramuscular injection comes as a powder to be mixed into a solution for injection, and a prefilled injection syringe. This medication is injected into a muscle, usually once a week, on the same day each week. It is best to give the injection around the same time of day on your injection days, usually in the late afternoon or evening. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use interferon beta-1a exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Interferon beta-1a controls the symptoms of MS, but does not cure it. Continue to take interferon beta-1a even if you feel well. Do not stop taking interferon beta-1a without talking to your doctor. You will receive your first dose of interferon beta-1a in your doctor's office. After that, you can inject interferon beta-1a yourself or have a friend or relative perform the injections. Before you use interferon beta-1a yourself the first time, read the written instructions that come with it. Ask your doctor or pharmacist to show you or the person who will be injecting the medication how to inject it. Always use a new, unopened vial or prefilled syringe and needle for each injection. Never reuse vials, syringes, or needles. Throw away used syringes in a puncture-resistant container, kept out of reach of children. Talk to your doctor or pharmacist about how to throw away the puncture-resistant container. You can inject interferon beta-1a in your upper arms or thighs. Use a different spot for each injection. Keep a record of the date and spot of each injection. Do not use the same spot two times in a row. Do not inject into an area where the skin is sore, red, bruised, scarred, infected, or abnormal in any way. To prepare interferon beta-1a powder for injection, follow these steps: Remove the vial from the refrigerator. Allow it to warm to room temperature for about 30 minutes before using. Do not use a heat source such as hot water or a microwave to warm the vial. Set up a clean, well lit, flat work surface, like a table, to collect all the supplies you will need. Assemble these supplies: vial of interferon beta-1a, vial of sterile water, sterile syringe, sterile needle, blue MICRO PIN (vial access pin), alcohol wipes and puncture-resistant container . Check the expiration date on the vials of interferon beta-1a powder and sterile water . Do not use if the medication or sterile water is expired. If either is expired, call your pharmacist. Wash your hands well with antibacterial soap. Remove the caps from the vials of interferon beta-1a powder and sterile water. Clean the rubber stopper on the top of each vial with an alcohol wipe. Remove the small light blue protective cover from the end of the syringe barrel with a counterclockwise (toward the left) turn. Attach the blue MICRO PIN to the syringe by turning clockwise (toward the right) until it is tight. Do not overtighten. Pull the MICRO PIN cover straight off, without twisting. Save the cover for later use. Pull back the syringe plunger to the 1.1-mL mark on the syringe. Firmly push the MICRO PIN on the syringe down through the center of the rubber stopper of the sterile water vial. Push down on the plunger of the syringe until it cannot be pushed down any farther. Keep the MICRO PIN in the vial and turn the vial and syringe upside down. Slowly pull back on the syringe plunger to the 1.1-mL mark. Gently tap the syringe with your finger to make any air bubbles rise to the top. If there are bubbles, slowly press the plunger in just enough to push the bubbles (but not liquid) out of the syringe. Make sure there is still 1.1 mL of sterile water in the syringe. Slowly pull the MICRO PIN out of the sterile water vial. Carefully push the MICRO PIN through the center of the rubber stopper of the interferon beta-1a powder vial. Pushing the MICRO PIN through the vial stopper off-center can cause the stopper to fall into the vial. If the stopper falls into the vial, do not use that vial. Get a new vial and continue to prepare your dose. Slowly push down on the plunger until the syringe is empty. Do not aim the stream of water directly on the medication powder . A forceful stream of liquid on the powder will cause foaming and make it difficult to withdraw the medication. Without removing the syringe, gently swirl the vial until the interferon beta-1a powder is dissolved. Do not shake. The solution should be clear to slightly yellow and should not have any particles. Do not use the vial if the solution is cloudy, has particles in it, or is another color. Turn the vial and syringe upside down. Slowly pull back on the plunger of the syringe until it is full to the 1.0-mL mark. If bubbles appear, push the solution slowly back into the vial and try again. Continue to hold the vial and syringe upside down. Tap the syringe gently to make any air bubbles rise to the top. Press the plunger in until the solution moves up to the top of the syringe and there is still 1.0 mL of solution left in the syringe. Pull the MICRO PIN out of the vial. Hold the syringe upright and carefully replace the cover on the MICRO PIN. Then remove the MICRO PIN from the syringe with a counterclockwise (to the left) turn. Attach the sterile needle for injection to the syringe by turning the needle clockwise (to the right) until it is tight. Throw away the blue MICRO PIN properly. See below for injection instructions. To prepare a prefilled syringe of interferon beta-1a intramuscular injection, follow these steps: Remove the prefilled syringe from the refrigerator and allow it to warm to room temperature for about 30 minutes before using. Do not use a heat source such as hot water or a microwave to warm the syringe. Check the syringe to be sure it is safe to use. The syringe should be labeled with the correct name of the medication and an expiration date that has not passed and should contain a clear, colorless solution filled to the 0.5-mL mark. If the syringe is expired, if the syringe contains a different amount of solution, or if the solution is cloudy, discolored, or contains any particles, do not use the syringe and call your pharmacist. Wash your hands well with antibacterial soap. Hold the prefilled syringe upright, with the rubber cap facing up. Remove the rubber cap by turning and gently pulling the cap in a clockwise (toward the right) direction. Open the needle package and attach the needle to the syringe by firmly pressing it onto the syringe and turning it a half-turn clockwise (toward the right). Be sure to attach the needle tightly so medication will not leak. To inject an intramuscular dose of interferon beta-1a, follow these steps: Set up a clean, well-lit, flat work surface, such as a table, to collect all the supplies you will need to inject your medication. Assemble these supplies: prefilled syringe, sterile needle, alcohol wipe, gauze pad, adhesive bandage, and puncture-resistant container. Use a new alcohol wipe to clean the skin in the spot where you will inject interferon beta-1a. Pull the protective cover straight off the needle without twisting. Use one hand to stretch the skin out around the spot where you will inject the medication. Use your other hand to hold the syringe like a pencil. Use a quick motion to stick the needle in the skin at a 90-degree angle (straight up and down) and push the needle through the skin and into your muscle. Let go of the skin and use that hand to gently pull back slightly on the syringe plunger. If you see blood come into the syringe, pull the needle out of the injection spot and put pressure on the spot with a gauze pad. You will need to replace the needle with a new needle, and choose a new spot for injection. If no blood comes into the syringe, slowly push the syringe plunger down until the syringe is empty. Hold a gauze pad near the needle at the injection spot and pull the needle straight out from the skin. Use the gauze pad to apply pressure to the spot for a few seconds or rub gently in a circular motion. If there is slight bleeding at the spot, wipe it off with the gauze pad, and, if necessary, apply an adhesive bandage. Throw away the used syringe and needle properly. After 2 hours, check the injection site for redness, swelling, or tenderness. If you have redness, swelling, or tenderness that does not go away in a few days or is severe, call your doctor.

Other uses for this medicine:

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Special precautions:

Before using interferon beta-1a, tell your doctor and pharmacist if you are allergic to interferon beta-1a, any other interferon product, any other medications, human albumin, natural rubber, or latex. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: acetaminophen (Tylenol, others), antidepressants, azathioprine (Imuran), cancer chemotherapy medications, carbamazepine (Tegretol), chloramphenicol (Chloromycetin), cholesterol-lowering medications (statins), cyclosporine (Neoral, Sandimmune), gold compounds such as auranofin (Ridaura) and aurothioglucose (Solganol), heparin, iron products, isoniazid (INH, Nydrazid), medications for acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV), methotrexate (Rheumatrex), niacin (nicotinic acid), penicillamine (Cuprimine, Depen), phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane), sirolimus (Rapamune), sulfa antibiotics such as sulfamethoxazole (Bactrim, Septra) and sulfisoxazole (Gantrisin), thyroid medications, and tacrolimus (Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had AIDS or HIV; an autoimmune disease (a disease in which the body attacks its own cells; ask your doctor if you are unsure if you have this type of disease); blood problems such as anemia (low red blood cells) or easy bruising or bleeding; cancer; depression, difficulty falling or staying asleep, or mental illness; seizures; or heart, liver, or thyroid disease. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using interferon beta-1a, call your doctor immediately. if you are having surgery, including dental surgery, tell the doctor or dentist that you are using interferon beta-1a. ask your doctor about the safe use of alcoholic beverages while you are using interferon beta-1a. Alcohol can make the side effects from interferon beta-1a worse. you should know that you may have flu-like symptoms such as headache, fever, chills, sweating, muscle aches, upset stomach, vomiting, and tiredness that last for a day after your injection. Your doctor may tell you to inject your medication at bedtime and take an over-the-counter pain and fever medication to help with these symptoms. These symptoms usually lessen or go away over time. Talk to your doctor if these symptoms last longer than the first few months of therapy, or if they are difficult to manage or become severe.

Special dietary instructions:

Unless your doctor tells you otherwise, continue your normal diet.

If I forget a dose:

Inject the missed dose as soon as you remember it. Do not inject interferon beta-1a two days in a row. Do not inject a double dose to make up for a missed dose. Return to your regular dosing schedule the following week. Call your doctor if you miss a dose and have questions about what to do.

What side effects:

Interferon beta-1a may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: tight muscles weakness stomach pain eye problems runny nose dizziness lightheadedness toothache joint pain hair loss bruising, pain, redness, swelling, or irritation in the place you injected interferon beta-1a Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately: depression thoughts of hurting yourself or others feeling very emotional seeing things or hearing voices that do not exist (hallucinating) seizures swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs trouble breathing when lying flat in bed increased need to urinate during the night decreased ability to exercise excessive tiredness lack of energy loss of appetite unexplained weight gain or loss chest pain or tightness fast or irregular heart beat swelling of hands, feet, ankles, or lower legs numbness, burning, tingling, or pain in hands or feet painful or difficult urination unusual bleeding or bruising pain in the upper right part of the stomach yellowing of the skin or eyes dark brown urine pale skin feeling cold or hot all the time sore throat, cough or other signs of infection hives skin rash itching difficulty breathing or swallowing hoarseness Interferon beta-1a may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions:

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the prefilled syringes and vials in the refrigerator. Do not freeze. If a refrigerator is not available, you can store the vials of interferon beta-1a at room temperature, away from heat and light, for up to 30 days. Always use vials of powder within 6 hours after you mix them with sterile water and use prefilled syringes within 12 hours after you take them out of the refrigerator. Throw away mixed vials or syringes after this time has passed. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of overdose:

In case of overdose, call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services at 911.

Other information:

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to interferon beta-1a. Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

More information:    Interferon beta-1a Intramuscular Injection

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