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Medroxyprogesterone Injection : Uses, Dosage, Contraindications, Side Effects, Overdose


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BRAND NAME :  Medroxyprogesterone Injection

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Medroxyprogesterone injection may decrease the amount of calcium stored in your bones. The longer you use this medication, the more the amount of calcium in your bones may decrease.The amount of calcium in your bones may not return to normal even after you stop using medroxyprogesterone injection.Loss of calcium from your bones may cause osteoporosis (a condition in which the bones become thin and weak) and may increase the risk that your bones might break at some time in your life, especially after menopause (change of life).The amount of calcium in the bones usually increases during the teenage years. A decrease in bone calcium during this important time of bone strengthening may be especially serious. It is not known whether your risk of developing osteoporosis later in life is greater if you start to use medroxyprogesterone injection when you are a teenager. Tell your doctor if you or anyone in your family has osteoporosis; if you have any other bone disease or anorexia nervosa (an eating disorder); or if you drink a lot of alcohol or smoke a great deal. Tell your doctor if you take any of the following medications: corticosteroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone), or medications for seizures such as carbamazepine (Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton).You should not use medroxyprogesterone injection for a long time (e.g., more than 2 years) unless no other method of birth control is right for you. Your doctor may test your bones to be sure they are not becoming too thin before you continue to use medroxyprogesterone injection.Keep all appointments with your doctor and the laboratory. Your doctor will monitor your health carefully to be sure you do not develop osteoporosis.Talk to your doctor about the risks of using medroxyprogesterone injection to prevent pregnancy.

Medication prescribed:

Medroxyprogesterone injection is used to prevent pregnancy. Medroxyprogesterone is in a class of medications called progestins. It works by preventing ovulation (the release of eggs from the ovaries). It also changes the lining of the uterus to prevent pregnancy from developing. Medroxyprogesterone injection is a very effective method of birth control but does not prevent the spread of human immunodeficiency virus [HIV, the virus that causes acquired immunodeficiency syndrome (AIDS)] or other sexually transmitted diseases.

How should this medicine be used:

Medroxyprogesterone injection comes as a suspension (liquid) to be injected into your buttocks or upper arm. It is usually given once every 3 months (13 weeks) by a health care provider in an office or clinic. You must receive your first medroxyprogesterone injection only at a time when there is no possibility that you are pregnant. Therefore, you may only receive your first injection during the first 5 days of a normal menstrual period, during the first 5 days after you give birth if you are not planning to breastfeed your baby, or during the sixth week after giving birth if you are planning to breastfeed your baby.

Other uses for this medicine:

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Special precautions:

Before using medroxyprogesterone injection, tell your doctor and pharmacist if you are allergic to medroxyprogesterone (Depo-Provera, Provera) or any other medications. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the medications listed in the IMPORTANT WARNING section and aminoglutethimide (Cytadren). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor if you have or have ever had, or anyone in your family has or has ever had, breast cancer. Also tell your doctor if you have or have ever had problems with your breasts such as lumps, bleeding from your nipples, an abnormal mammogram (breast x-ray), or fibrocystic breast disease (swollen, tender breasts and/or breast lumps that are not cancer); unexplained vaginal bleeding; irregular or very light menstrual periods; excessive weight gain or fluid retention before your period; blood clots in your legs, lungs, brain, or eyes; stroke or mini-stroke; migraine headaches; seizures; depression; diabetes; high blood pressure; asthma; or heart, liver, or kidney disease. tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while using medroxyprogesterone injection, call your doctor immediately. Medroxyprogesterone may harm the fetus. tell your doctor if you are breastfeeding. You may use medroxyprogesterone injection while you are breastfeeding as long as your baby is 6 weeks old when you receive your first injection. Some medroxyprogesterone may be passed to your baby in your breast milk but this has not been shown to be harmful. Studies of babies who were breastfed while their mothers were using medroxyprogesterone injection showed that the babies were not harmed by the medication. if you are having surgery, including dental surgery, tell the doctor or dentist that you are using medroxyprogesterone injection. you should know that your menstrual cycle will probably change while you are using medroxyprogesterone injection. At first, your periods will probably be irregular, and you may experience spotting between periods. If you continue to use this medication, your periods may stop completely. Your menstrual cycle will probably return to normal some time after you stop using this medication.

Special dietary instructions:

You should eat plenty of foods that are rich in calcium and vitamin D while you are taking medroxyprogesterone injection to decrease the loss of calcium from your bones. Your doctor will tell you which foods are good sources of these nutrients and how many servings you need each day. Your doctor also may prescribe or recommend calcium or vitamin D supplements.

If I forget a dose:

If you miss an appointment to receive an injection of medroxyprogesterone, call your doctor right away.You may not be protected from pregnancy if you do not receive your injections on schedule every 13 weeks. If more than 13 weeks have passed since your last injection, your doctor will probably administer a pregnancy test to be sure that you are not pregnant before giving you your next injection.

What side effects:

Although side effects from medroxyprogesterone are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away: spotting or bleeding between menstrual periods lack of menstrual periods weight gain tiredness nervousness depression difficulty falling asleep or staying asleep hot flashes breast pain stomach cramps or bloating leg cramps back or joint pain acne loss of hair on scalp swelling, redness, irritation, burning, or itching of the vagina white vaginal discharge changes in sexual desire Some side effects can be serious. The following side effects are uncommon, but if you experience any of them, call your doctor immediately: sudden shortness of breath sudden sharp or crushing chest pain coughing up blood severe headache upset stomach dizziness or faintness change or loss of vision double vision bulging eyes difficulty speaking weakness or numbness in an arm or leg seizure yellowing of the skin or eyes pain, swelling, warmth, redness, or tenderness in one leg only vaginal bleeding that is heavier or lasts longer than normal severe pain or tenderness just below the waist ongoing pain, pus, or bleeding at the place where the injection was given rash hives itching difficulty breathing or swallowing swelling of the hands, feet, ankles, or lower legs yellowing of the skin or eyes difficult, painful, or frequent urination If you are younger than 35 years old and began to receive medroxyprogesterone injection in the last 4–5 years, you may have a slightly increased risk that you will develop breast cancer. Medroxyprogesterone injection may also increase the chance that you will develop a blood clot that moves to your lungs or brain. Talk to your doctor about the risks of using this medication. Medroxyprogesterone injection is a long-acting birth control method. You might not become pregnant for some time after you receive your last injection. Talk to your doctor about the effects of using this medication if you plan to become pregnant in the near future. Medroxyprogesterone injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

What storage conditions:

Your doctor will store the medication in his or her office.

In case of overdose:

In case of overdose, call your local poison control center. If the victim has collapsed or is not breathing, call local emergency services at 911.

Other information:

You should have a complete physical exam, including blood pressure measurements, breast and pelvic exams, and a Pap test, at least yearly. Follow your doctor's directions for examining your breasts; report any lumps immediately. Before you have any laboratory tests, tell the laboratory personnel that you are using medroxyprogesterone.

More information:    Medroxyprogesterone Injection

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