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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



Mellaril

Pronounced: MEL-ah-rill
Generic name: Thioridazine hydrochloride


Why is this drug prescribed: Mellaril combats the crippling mental disorder known as schizophrenia (a severe loss of contact with reality). Because Mellaril has been known to cause dangerous heartbeat irregularities, it is usually prescribed only when at least two other medications have failed.

Most important fact about this drug: The danger of potentially fatal cardiac irregularities increases when Mellaril is combined with any medication that prolongs a part of the heartbeat known as the QTc interval. Many of the drugs prescribed for heartbeat irregularities (including Cordarone, Inderal, Quinaglute, Quinidex, and Rythmol) prolong the QTc interval and should never be combined with Mellaril. Other drugs to avoid when taking Mellaril include Luvox, Norvir, Paxil, Pindolol, Prozac, Rescriptor, and Tagamet. Make sure the doctor knows you are taking Mellaril whenever a new drug is prescribed.

How should you take this medication: If you are taking Mellaril in a liquid concentrate form, you can dilute it with a liquid such as distilled water, soft tap water, or juice just before taking it. Do not change from one brand of thioridazine to another without consulting your doctor. --If you miss a dose... If you take 1 dose a day and remember later in the day, take the dose immediately. If you don't remember until the next day, skip the dose and go back to your regular schedule. If you take more than 1 dose a day and remember the forgotten dose within an hour or so after its scheduled time, take it immediately. If you don't remember until later, skip the dose and go back to your regular schedule. Never try to "catch up" by doubling a dose. --Storage instructions... Store at room temperature, tightly closed, in the container the medication came in.

What side effects may occur: Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Mellaril. Side effects may include: Abnormal and excessive secretion of milk, agitation, anemia, asthma, blurred vision, body spasm, breast development in males, changed mental state, changes in sex drive, chewing movements, confusion (especially at night), constipation, diarrhea, discolored eyes, drowsiness, dry mouth, excitement, eyeball rotation, fever, fluid accumulation and swelling, headache, inability to hold urine, inability to urinate, inhibition of ejaculation, intestinal blockage, involuntary movements, irregular blood pressure, pulse, and heartbeat, irregular or missed menstrual periods, jaw spasm, loss of appetite, loss of muscle movement, mouth puckering, muscle rigidity, nasal congestion, nausea, overactivity, painful muscle spasm, paleness, pinpoint pupils, protruding tongue, psychotic reactions, puffing of cheeks, rapid heartbeat, redness of the skin, restlessness, rigid and masklike face, sensitivity to light, skin pigmentation and rash, sluggishness, stiff, twisted neck, strange dreams, sweating, swelling in the throat, swelling or filling of breasts, swollen glands, tremors, vomiting, weight gain, yellowing of the skin and whites of eyes

Why should this drug not be prescribed: Due to the danger of cardiac irregularities, Mellaril must never be combined with drugs that increase its effects or prolong the part of the heartbeat known as the QTc interval. (See "Most important fact about this drug.") It is also important to avoid combining Mellaril with excessive amounts of central nervous system depressants such as alcohol, barbiturates, or narcotics. Do not take Mellaril if you have heart disease accompanied by severe high or low blood pressure.

Special warnings about this medication: Mellaril may cause tardive dyskinesia--a condition marked by involuntary muscle spasms and twitches in the face and body. This condition may be permanent, and appears to be most common among the elderly, especially women. Ask your doctor for information about this possible risk. Drugs such as Mellaril are also known to cause a potentially fatal condition known as Neuroleptic Malignant Syndrome. Symptoms of this problem include high fever, rigid muscles, altered mental status, sweating, fast or irregular heartbeat, and changes in blood pressure. If you develop these symptoms, see your doctor immediately. Mellaril therapy may have to be permanently discontinued. In rare cases, Mellaril has been known to trigger blood disorders and seizures. It can cause dizziness or faintness when you first stand up. High doses can also cause vision problems, including blurring, brownish coloring of vision, and poor night vision. This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness until you are certain the drug will not interfere. If you have ever had breast cancer, make sure your doctor is aware of it. Mellaril may cause false positive results in tests for pregnancy.

Possible food and drug interactions when taking this medication: Remember that combining Mellaril with certain drugs can increase the danger of potentially fatal heartbeat irregularities. Among the drugs to avoid are the following: Amiodarone (Cordarone) Cimetidine (Tagamet) Delavirdine (Rescriptor) Fluoxetine (Prozac) Fluvoxamine (Luvox) Paroxetine (Paxil) Pindolol Propafenone (Rythmol) Propranolol (Inderal) Quinidine (Quinaglute, Quinidex) Ritonavir (Norvir) Check with your doctor before adding any new drug to your regimen. Remember, too, that extreme drowsiness and other potentially serious effects can result if Mellaril is combined with alcohol or other central nervous system depressants such as narcotics, painkillers, and sleeping medications.

Special information if you are pregnant or breastfeeding: Pregnant women should use Mellaril only if clearly needed. If you are pregnant or plan to become pregnant, inform your doctor immediately.

Recommended dosage: Your doctor will tailor your dose to your needs, using the smallest effective amount. ADULTS: The starting dose ranges from 50 to 100 milligrams 3 times a day. Your doctor may gradually increase your dosage to as much as 800 milligrams a day, taken in 2 to 4 small doses. Once your symptoms improve, your doctor will decrease the dosage to the lowest effective amount. CHILDREN: The usual starting dose for schizophrenic children is 0.5 milligrams per 2.2 pounds of body weight per day, divided into smaller doses. The dose may be gradually increased to a maximum of 3 milligrams per 2.2 pounds per day.

Overdosage: Any medication taken in excess can have serious consequences. An overdose of Mellaril can be fatal. If you suspect an overdose, seek medical help immediately. Symptoms of Mellaril overdose may include: Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock









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