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Triavil

Pronounced: TRY-uh-vill
Generic ingredients: Amitriptyline hydrochloride, Perphenazine
Other brand name: Etrafon


Why is this drug prescribed: Triavil is used to treat anxiety, agitation, and depression. Triavil is a combination of a tricyclic antidepressant (amitriptyline) and a tranquilizer (perphenazine). Triavil can also help people with schizophrenia (distorted sense of reality) who are depressed and people with insomnia, fatigue, loss of interest, loss of appetite, or a slowing of physical and mental reactions.

Most important fact about this drug: Triavil may cause tardive dyskinesia--a condition marked by involuntary muscle spasms and twitches in the face and body. This condition may be permanent and appears to be most common among the elderly, especially women. Ask your doctor for information about this possible risk.

How should you take this medication: Triavil may be taken with or without food. You should not take it with alcohol. --If you miss a dose... Take it as soon as you remember. If it is within 2 hours of your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once. --Storage instructions... Store at room temperature in a tightly closed container. Protect Triavil 2-10 tablets from light.

What side effects may occur: Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Triavil. Side effects may include: Abnormal secretion of milk, abnormalities of movements and posture, anxiety, asthma, black tongue, blood disorders, blurred vision, body rigidly arched backward, breast development in males, change in pulse rate, chewing movements, coma, confusion, constipation, convulsions, delusions, diarrhea, difficulty breathing, difficulty concentrating, difficulty swallowing, dilated pupils, disorientation, dizziness, drowsiness, dry mouth, eating abnormal amounts of food, ejaculation failure, episodes of elation or irritability, excessive or spontaneous flow of milk, excitement, exhaustion, eye problems, eye spasms, eyes in a fixed position, fatigue, fever, fluid accumulation and swelling (including throat and brain, face and tongue, arms and legs), frequent urination, hair loss, hallucinations, headache, heart attacks, hepatitis, high blood pressure, high fever, high or low blood sugar, hives, impotence, inability to stop moving, inability to urinate, increased or decreased sex drive, inflammation of the mouth, insomnia, intestinal blockage, intolerance to light, involuntary jerky movements of tongue, face, mouth, lips, jaw, body, or arms and legs, irregular blood pressure, pulse, and heartbeat, irregular menstrual periods, lack of coordination, light-headedness upon standing up, liver problems, lockjaw, loss or increase of appetite, low blood pressure, muscle stiffness, nasal congestion, nausea, nightmares, odd taste in the mouth, overactive reflexes, pain and stiffness around neck, palpitations, protruding tongue, puckering of the mouth, puffing of the cheeks, purple-reddish-brown spots on skin, rapid heartbeat, restlessness, rigid arms, feet, head, and muscles, ringing in the ears, salivation, sedation, seizures, sensitivity to light, severe allergic reactions, skin rash or inflammation, scaling, spasms in the hands and feet, speech problems, stomach upset, stroke, sweating, swelling of breasts, swelling of testicles, swollen glands, tingling, pins and needles, and numbness in hands and feet, tremors, twisted neck, twitching in the body, neck, shoulders, and face, uncontrollable and involuntary urination, urinary problems, visual problems, vomiting, weakness, weight gain or loss, writhing motions, yellowed skin and whites of eyes

Why should this drug not be prescribed: You should not be using Triavil if you are taking drugs that slow down the central nervous system, including alcohol, barbiturates, analgesics, antihistamines, or narcotics. Triavil should not be used if you are recovering from a recent heart attack, or if you have an abnormal bone marrow condition. Avoid Triavil if you have ever had an allergic reaction to phenothiazines or amitriptyline. People who are taking antidepressant drugs known as MAO inhibitors (including Nardil and Parnate) should not take Triavil.

Special warnings about this medication: Before using Triavil, tell your doctor if you have ever had: the eye condition known as glaucoma; difficulty urinating; breast cancer; seizures; heart, liver, or thyroid disease; or if you are exposed to extreme heat or pesticides. Be aware that Triavil may mask signs of brain tumor, intestinal blockage, and overdose of other drugs. Nausea, headache, and a general ill feeling can result if you suddenly stop taking Triavil. Follow your doctor's instructions closely when discontinuing Triavil. If your dose is gradually reduced, you may experience irritability, restlessness, and dream and sleep disturbances, but these effects will not last. This drug may impair your ability to drive a car or operate potentially dangerous machinery. Do not participate in any activities that require full alertness if you are unsure about your ability. If you develop a fever that has no other cause, stop taking Triavil and call your doctor.

Possible food and drug interactions when taking this medication: If Triavil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Triavil with the following: Airway-opening drugs such as Proventil Antiseizure drugs such as Dilantin Antidepressant drugs classified as MAO inhibitors, including Nardil and Parnate Antihistamines such as Benadryl Antispasmodic drugs such as Bentyl Atropine (Donnatal) Barbiturates such as phenobarbital Blood-thinning drugs such as Coumadin Cimetidine (Tagamet) Disulfiram (Antabuse) Epinephrine (EpiPen) Ethchlorvynol (Placidyl) Fluoxetine (Prozac) Furazolidone (Furoxone) Guanethidine (Ismelin) Major tranquilizers such as Haldol Narcotic analgesics such as Percocet Thyroid medications such as Synthroid Extreme drowsiness and other potentially serious effects can result if Triavil is combined with alcohol or other central nervous system depressants such as narcotics, painkillers, and sleep medications.

Special information if you are pregnant or breastfeeding: Triavil may cause false-positive results on pregnancy tests. Triavil should not be used by pregnant women or mothers who are breastfeeding.

Recommended dosage: Your doctor will individualize your dose. You should not take more than 4 tablets of Triavil 4-50 or 8 tablets of any other strength in one day. It may be a few days to a few weeks before you notice any improvement. ADULTS: For Non-Psychotic Anxiety and Depression The usual dose is 1 tablet of Triavil 2-25 or 4-25 taken 3 or 4 times a day, or 1 tablet of Triavil 4-50 taken twice a day. For Anxiety in People with Schizophrenia The usual dose is 2 tablets of Triavil 4-25 taken 3 times a day. Your doctor may tell you to take another tablet of Triavil 4-25 at bedtime, if needed. If you need to keep taking Triavil, your doctor will probably have you take 1 tablet of Triavil 2-25 or 4-25 from 2 to 4 times a day or 1 tablet of Triavil 4-50 twice a day. CHILDREN: Children should not use Triavil. OLDER ADULTS AND ADOLESCENTS: For Anxiety The usual dose is 1 tablet of Triavil 4-10, taken 3 or 4 times a day. People in these age groups usually take Triavil at lower doses.

Overdosage: Any medication taken in excess can have serious consequences. An overdose of Triavil can be fatal. If you suspect an overdose, seek medical help immediately. Symptoms of Triavil overdose may include: Abnormalities of posture and movements, agitation, coma, convulsions, dilated pupils, drowsiness, extreme low body temperature, eye movement problems, high fever, heart failure, overactive reflexes, rapid or irregular heartbeat, rigid muscles, stupor, very low blood pressure, vomiting









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